13- 15ĭonor risk factors impacting graft success have been integrated into predictive scores for organ allocation 16 however, we have previously shown that light microscopy analyses alone are insufficient to resolve the full extent of subcellular acute stress in the pancreas. Various interventions and technologies have been developed to reduce or reverse the injuries to donor organs in the transplantation process, such as preservation solution additives, normothermic and hypothermic machine perfusion, and persufflation. 6- 10 In particular, increased cold ischemia time (CIT) is associated with poorer isolated-islet yield and reduced graft survival. 5ĭonor organs are subjected to multiple stresses during the peritransplant process, including stress associated with the following: death, trauma, intensive care management, organ procurement, and processing, which can adversely impact upon recipient outcomes. 1 Transplantation of the vascularized whole pancreas or isolated islets can restore glycemic control in suitable recipients, 2- 4 although β-cell loss and failure to attain or maintain insulin independence are frequent occurrences following islet transplantation. Insulin-dependent type 1 diabetes (T1D) is characterized by loss of endocrine β cells within the islets of Langerhans in the pancreas associated with autoimmunity.
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